Veg Capsule
Methylfolate 5000 mcg
Nervous System Support
$32.00
$1.07 a day · 30-day supply
Folate in its active methylated form as Quatrefolic, suitable for those with an MTHFR variant. Folate is required for DNA synthesis and DNA repair in dividing cells.
In depth
About this supplement
What Is Methylfolate 5000 mcg?
Folate is vitamin B9. Most supplements supply folic acid, a synthetic form the body has to work through several enzyme steps before it can use it. This capsule skips the queue and supplies (6S)-5-methyltetrahydrofolate, the form folate already takes in the bloodstream.
How It Works in the Body
Folate's job is carrying single carbon atoms from one reaction to another, and two kinds of work depend on that. The first is building DNA: folate donates the carbon that turns uracil into thymine, so every dividing cell needs a steady supply. Bone marrow making red blood cells and the fast-turnover lining of the gut are first in line.
The second is methylation. 5-MTHF hands its methyl group over in the reaction that regenerates methionine, and methionine goes on to become SAM-e, the body's general-purpose methyl donor. Vitamin B12 is required at that hand-off, which is why the two nutrients travel together.
What It Supports
- Cell division: Folate is required for DNA synthesis and DNA repair in dividing cells.
- Red blood cells: Folate plays a role in normal red blood cell formation.
- Methylation: 5-MTHF supports the methylation cycle that produces SAM-e.
- Amino acid metabolism: Folate contributes to normal amino acid metabolism.
Who It May Suit
This is the high-strength option, the one practitioners tend to reserve for people they are working with directly. It may also suit anyone eating little in the way of leafy greens, legumes and liver, or following a gluten-free pattern, since gluten-free grain products are rarely fortified with folic acid.
Good To Know
Folate is declared in dietary folate equivalents, so the figure is 8,333 mcg DFE per serving: a conversion factor, not a second ingredient. A high folate intake can mask the blood signs of vitamin B12 deficiency while nerve damage continues, so talk with your provider before use, particularly if you take methotrexate or an antiseizure medicine.
At a glance
Allergens and certifications
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01
Vegan
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02
Kosher
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03
Halal
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04
Non-GMO
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05
Gluten free
FAQ
Common questions
What is Methylfolate 5000 mcg?
Folate, vitamin B9, in its already-methylated form: (6S)-5-methyltetrahydrofolate at 5,000 mcg per serving in a vegetarian capsule. This is the form folate circulates as in blood, rather than folic acid, which the body has to work through several enzyme steps before it can be used.
How does it work?
Folate carries one-carbon units. Those carbons build the thymine in DNA and supply the methyl group that regenerates methionine, which the body turns into SAM-e, its main methyl donor. Vitamin B12 is required for that hand-off, so folate and B12 effectively work as a pair.
What makes this form different?
Its form and its labeling. The methylfolate is 5,000 mcg per serving, and because folate is declared in dietary folate equivalents that reads as 8,333 mcg DFE per serving. The source is Quatrefolic, a glucosamine salt of (6S)-5-MTHF, in a capsule rather than a tablet.
Who is it for?
People who would rather take the methylated form, and whose diets are short on leafy greens, legumes and liver. Gluten-free eaters are worth a mention: fortified wheat flour is a major folic acid source in the food supply, and gluten-free products usually skip that fortification.
What should I know before taking it?
Talk with your provider before use, especially if you take methotrexate, sulfasalazine or an antiseizure medicine, since all three interact with folate. A high folate intake can also hide the blood picture of vitamin B12 deficiency, so B12 is worth checking alongside it.
Ingredients
What is in it
Every ingredient, as listed on the label.
Supplement Facts
Serving Size 1 veg capsule
| Ingredient | Amount Per Serving | % DV |
|---|---|---|
| Folate | 8333 mcg | 2083% |
| [5,000 mcg (6S)-5-MTHF] | ||
| [from Quatrefolic® (6S)-5-MTHF Glucosamine Salt] |
Other Ingredients: Microcrystalline Cellulose, Hypromellose (cellulose capsule), Stearic Acid (vegetable source).
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