Veg Capsule
5-HTP Plus
Mood & Sleep Support
$17.00
$0.57 a day · 30-day supply
A dual-action formula featuring highly bioavailable forms of vitamin B12 (methylcobalamin and adenosylcobalamin) and folate (Quatrefolic®) to support neurological health, energy production, red blood cell formation, and methylation.
In depth
About this supplement
What Is 5-HTP Plus?
5-HTP is the molecule your body makes from the amino acid tryptophan, one step short of serotonin. The supplement form is not built in a lab; it is pressed from the seeds of Griffonia simplicifolia, a climbing shrub from West Africa. This formula pairs it with vitamin B6 as pyridoxal-5-phosphate.
How It Works in the Body
Serotonin is built in two steps. Tryptophan becomes 5-HTP, then 5-HTP becomes serotonin. The first step is the tightly controlled one, and starting from 5-HTP steps past it.
The enzyme that handles the second step, aromatic L-amino acid decarboxylase, cannot act without pyridoxal-5-phosphate bound to it. That is the active form of vitamin B6, and it is why both sit in the same capsule.
What It Supports
- A calm, balanced mood: Serotonin signalling supports a calm, balanced mood.
- Restful sleep: The body converts serotonin onward to melatonin, so 5-HTP supports restful sleep.
- Normal appetite signalling: Serotonin is involved in how the brain reads fullness during a meal.
- Amino acid metabolism: Pyridoxal-5-phosphate acts as a cofactor in well over a hundred enzyme reactions.
Who It May Suit
The capsule is cellulose and the rest of the formula is cellulose and L-leucine, so it fits vegetarian and vegan patterns. It is made for adults. Two actives and nothing else may appeal to people who already take a B-complex, or who like knowing exactly what they are taking.
Good To Know
Pyridoxal-5-phosphate is the form of B6 that enzymes bind directly, with no conversion step first. Talk with your healthcare provider before use, especially if you take migraine medication such as a triptan or an antidepressant. Both act on the same serotonin pathway as 5-HTP, and combining them raises the risk of serotonin syndrome.
At a glance
Allergens and certifications
-
01
Vegan
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02
Non-GMO
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03
Gluten free
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04
Soy free
-
05
Dairy free
FAQ
Common questions
What is 5-HTP Plus?
5-HTP Plus is a two-ingredient capsule: 5-hydroxytryptophan together with vitamin B6 in its pyridoxal-5-phosphate form. 5-HTP is what the body makes from tryptophan on the way to serotonin. The supplement version comes from the seeds of Griffonia simplicifolia, a shrub native to West Africa.
How does it work?
Once absorbed, 5-HTP crosses into the brain, where aromatic L-amino acid decarboxylase converts it to serotonin. That enzyme only works with pyridoxal-5-phosphate attached. Because the formula supplies 5-HTP rather than tryptophan, it begins after the body's main control point on serotonin synthesis, which sits at the first step.
What makes this formula different?
Two actives, nothing padding them out: 5-HTP at 100 mg per serving, vitamin B6 at 20 mg per serving. The B6 is pyridoxal-5-phosphate rather than pyridoxine, so it is the shape the enzyme binds. Pairing a precursor with the cofactor its enzyme needs is the whole idea of the formula.
Who is it for?
The capsule is cellulose, so the formula fits vegetarian and vegan patterns. It is made for adults, not children. It may suit people who like a short ingredient list, and anyone who wants B6 as pyridoxal-5-phosphate rather than as pyridoxine, which the liver has to convert before enzymes can use it.
What should I know before taking it?
Read this one first. Talk with your healthcare provider before use if you take migraine medication such as a triptan, an antidepressant of any class, tramadol, or a Parkinson's medication such as carbidopa. All of them act on the serotonin pathway, and combining them raises the risk of serotonin syndrome. The same applies if you are pregnant or nursing.
Ingredients
What is in it
Every ingredient, as listed on the label.
Supplement Facts
Serving Size 1 veg capsule
| Ingredient | Amount Per Serving | % DV |
|---|---|---|
| Vitamin B-6 (as Pyridoxal-5-Phosphate) | 20 mg | 1176% |
| 5-HTP (5-Hydroxytryptophan) | 100 mg | † |
† Daily Value not established.
Other Ingredients: Microcrystalline cellulose, cellulose (capsule), L-leucine.
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